EVALUATION OF MILLET STARCHES (Pennisetum glaucum and Pennisetum americanum) AS TABLET BINDERS AND DISINTEGRANTS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
Abstract
Starch was extracted from the two varieties of millet (Pennisetum glaucum and Pennisetum americanum) by the wet extraction method, the percentage yield was determined. The physicochemical properties investigated includes: flow rate, angle of repose, carr’s index, tapped density, bulk density, moisture content, swelling capacity, particle size, solubility, iodine test, and hausner ratio. Granules were prepared by the wet granulation method of massing and screening using the two varieties of millet starches as disintegrants and binders in one formulation and comparing their physicochemical properties with that of maize starch BP. Paracetamol tablets were formulated using Pennisetum glaucum and Pennisetum americanum starch as binder and disintegrant compared with maize starch and studying the tableting properties of the tablets produced. The percentage yields of starch from the two varieties of millet were found to be 50% for Pennisetum glaucum and 56.8% for Pennisetum americanum. The two starches have similar flow, swelling, power and moisture sorption properties. The suitability of millet starches as binders and disintegrants at various concentrations were investigated in tablet formulations using paracetamol as the medicinal substances. The millet starches (Pennisetum glaucum and Pennisetum americanum) formulations were compared for hardness, friability, disintegration time against maize starch formulations. Using the same concentrations of binders and disintegrants. The results indicated that millet starches were suitable binders and Disintegrants. When the disintegrant and binding properties were analysed and compared with maize starch There was an increase in tablet crushing strength as the disintegrant concentration xix increased. There was also a decrease in the friability of the tablets as binder concentration increased. Disintegration time was found to increase with increase in binder concentration.
Related Project Materials
THE IMPACT OF INTERNAL CONTROL SYSTEM ON REVENUE GENERATION: (A CASE STUDY OF POWER HOLDING COMPANY OF NIGERIA (P.H.C.N) OKPARA AVENUE ENUGU)
ABSTRACT
The objective of this study was to evaluate the internal control system in...
A STATISTICAL ANALYSIS OF THE ROLE OF MICRO-FINANCE BANK IN AGRICULTURAL DEVELOPMENT
The thesis statistically analyzed of the role of microfinance bank in agricultural development in Nasarawa state. The study cover three select...
ROLE OF TRANSPORTATION AND COMMUNICATION IN THE ECONOMIC DEVELOPMENT OF NIGERIA
ABSTRACT
This research work was designed to survey the role of transportation and communication to the economic developm...
IMPACT OF RUNNING SEPARATE HOME BY MARRIED COUPLES ON WIFE AND CHILDREN
ABSTRACT
The main involvement of the study was an investigation into the problems and prospect of runni...
THE IMPACT OF ECONOMIC GROWTH IN POVERTY ALLEVIATION IN NIGERIA
Background Of The Study
The history of Nigeria's economic growth has been somewhat turbulent. Accor...
AN ASSESSMENT OF COMMUNICATION AND GOOD GOVERNANCE
Background to the study
Communication is the most general form of interpersonal interaction required fo...
PERCEIVED DETERMINANTS OF ROAD TRAFFIC ACCIDENT AMONG AUTOMOBILE ROAD USERS
ABSTRACT
This study was undertaken to examine the perceived determinants of road traffic accidents amon...
THE ROLE OF BROADCAST MEDIA IN ACHIEVING VISION 20:20:20
ABSTRACT
This research work crucially examined “The role of broadcast media in achieving vision 20:2020”...
Knowledge Management practices in construction organisation
Statement of the Problem
There is the need for the construction organisation to reflect and take decision on timely basis as the construc...
AMERICAN UNIVERSITY OF NIGERIA SAFESHOP
ABSTRACT
Trust is a major factor in the internet business. This is not surprising as it is very convenient for cyber criminals to swindle...
